[KSCCM-COVID19] 관련논문 1
작성자
KSCCM작성일자
2021-01-05 00:00조회수
901
Managing
intensive care admissions when there are not enough beds during the COVID-19
pandemic: a systematic review
Tyrrell CSB, et al.
Thorax. 2020.
COVID-19 3차 유행으로 중환자들이 급격히 늘면서, 제한된 인력과 중환자 병상으로 인해, 중환자실 입실 기준 (triage decision) 에 대한 많은 고민들이 있습니다. 본
저널은 COVID-19 대유행 시기 동안 제한된 의료자원을 가지고, 누구에게
기계환기 같은 potentially life-saving treatment을 적용해야 할 지 결정해야
하는 의료진을 도와주기 위해 여러 나라들에서 발표한 중환자 입실기준에 대한 가이드라인들의 체계적 문헌고찰을 통해,
일선에서 근무하는 의료진들에게 방향성을 제시하고자 하였습니다.
쳬계적 문헌고찰에 포함된 7개의 가이드라인들을 9가지 항목으로 분류하여 표1에 정리하였습니다.
<표1>
|
Toolkit for COVID-19— Kansas Department for Health and Environment (Kansas,
USA) |
Clinical ethics recommendations for the allocation of intensive care treatments in exceptional resource-limited circumstances— Italian Society of Anaesthesia, Analgesia and Intensive Care (SIAARTI) |
The Australian and New Zealand Intensive Care Society COVID-19 Guidelines v1 |
Ethical principles concerning proportionality of critical care during the COVID-19 pandemic: advice by the
Belgian Society of Intensive Care Medicine |
Department of Defense COVID-19 practice management guide (US
military hospitals) |
COVID-19 pandemic: triage for intensive care treatment under resource scarcity—Swiss Academy of Medical Sciences |
COVID-19 rapid guideline: critical care in adults—National Institute
for Health and Care Excellence (NICE) (UK) |
1. Development
of guideline process |
By expert
panel |
By expert
panel |
Consensus-based |
By expert
panel |
By expert
panel |
Based on
previous pandemic
guidelines. Adapted
by experts |
Evidence
review and rapid consultation |
2. Ethical Framework: distributive justice « triage
criteria for allocating resource |
Emphasizes
maximising lives saved. For
patients of similar risk-benefit category,
allocation should be at random or first come, first served. |
Maximize benefits for the greatest number
of people. Discusses
possible need of using first come, first served during resource saturation. |
Emphasizes maximising lives saved. |
Emphasizes maximising lives saved. |
|
Maximising lives saved is a
decisive factor for purposes of triage. Acknowledges importance
of equity and
protecting healthcare professionals. |
|
3. Criteria for admission |
Primarily
medical survivability
determined by clinical judgement or formal means (eg, SOFA score). Exclusion
criteria for severe conditions
(eg, metastatic disease with poor prognosis, end-stage organ failure). |
Age (with possible upper
limit); comorbidities; functional
status. |
Probable outcome of the
patient’s condition;
burden of ICU
treatment; comorbidities; likelihood
of response to treatment. |
Probable outcome of patient’s condition; frailty in elderly patients (eg, Clinical Frailty Score); cognitive impairment
in elderly patients; comorbidities (particularly
severe or life-limiting conditions); age alone
should not be used |
Each
hospital should provide a specific plan regarding ICU admission/exclusion criteria. Age and comorbidities should be
a factor for
provision of (any form of)
care for older patients. |
Patients
who are most likely to survive to discharge. Specific
exclusion criteria
given, primarily related to severe life-limiting underlying conditions; when
no ICU beds available, a broader set of conditions and any patient aged
>85 years, regardless of underlying
health. |
Based on likelihood of recovery. Frailty (using
Clinical Frailty Score or individualised assessment
of frailty if score not appropriate); comorbidities; patient
wishes. |
4.
Criteria adapt as demand changes |
Yes.
Hospitals should adapt based on resources. |
Yes.
Criteria need to be
flexible based on resource
availability. |
Yes,
living document will be continually revised. |
|
Yes. Different
criteria for different levels of capacity |
Two sets
of criteria : (A)
capacity limited, (B) no beds available. |
|
5.
Criteria for discharge |
Yes. Reassess
every 48 hours, with step down if exclusion criteria are met. |
No
explicit criteria, de-escalation
decisions should not be postponed. |
|
|
|
Yes. Reassess every 48 hours with specific clinical discontinuation criteria
given |
No
explicit criteria but stop when not achieving outcomes |
6. Equality
between
COVID-19 and other health conditions |
|
Yes |
Yes |
Yes |
|
Yes |
Yes |
Elective
procedure and non-urgent hospital care ¯ |
|||||||
7.
Equality across healthcare system |
Ventilated
patients in chronic care facilities would not be
subjected to acute care triage guidelines. Uniform
policies are required
to avoid inequalities |
Partially—principles established
but anticipate
different thresholds
locally based on local capacity and demand. |
While
similar criteria
should apply across
all jurisdictions, the
ultimate decision-making is at
discretion of senior
intensive care medical staff. |
Each
hospital drafts their own
ethical guideline |
Each
hospital should
have their own criteria and implement based on their own resources |
Yes.
Uniform criteria across
the country |
Hospitals
should discuss sharing of resources
and transfer patients between units in other hospitals to ensure best use of critical
care |
8. Decision-making processes and support |
Triage team (medically led and independent of treating doctor) will make
decisions on resource
allocation for individual patients, and its decision-making scrutinised
by a ‘review committee’. |
Decision-making responsibility
is for doctors managing care—suggests second
opinion for challenging cases. |
Treating clinician responsible
for decision-making. Shared decision-making with
other clinicians |
Decision
to deny or prioritise
treatment made by
two or three doctors in consultation. Psychological
support offered to clinicians making triage decisions. Keep
register of all triage
decisions |
|
Decisions
to be made by multidisciplinary team, which
may include input from ethicists. Most senior
clinician takes responsibility. Deviation from guidance possible but must
be clearly stated
why |
Decision-making
is by the critical care team. |
9.
Communication of decision |
|
Yes.
Communicate decisions
with patients and obtain their wishes. |
Yes.
Shared and transparent
decision-making process with patients
and relatives |
Yes. Open communication
with patient
and family |
Providers
should avoid discussing rationing of care at
the bedside |
Discussed
but must be transparent. |
Open communication
with patient and family and shared decision-making |
ECMO 적용 결정은, ELSO guideline에서는 경미한 병증을 지닌 젊은 환자나 의료종사자에 우선 순위를 적용하고, 중증이거나 7일 이상 기계환기를 시행한 환자는 제외 기준에 넣었다. 21일 이상 심폐기능의 호전이 없으면 de-escalation 을 권유하였다
요약하자면 대부분의 가이드라인에서 ‘triage’ 의 중요성을 언급하였고, 제한된 의료자원의 배분을 위해 윤리적 측면을 고려하여 입실과 퇴실 기준 의 중요성을 기술하였다. 또한 가이드라인은 의료체계 전반적으로 공정하고 동일하게 적용될 수 있는 원칙을 포함해야 한다.
증거 기반 지침 (evidence-based guidelines)의 수립은 의료 현장에서 일관성 있는 치료를 유지하고 어려운 의사 결정 시 임상의들의 부담을 경감시키고. 환자의 예후를 향상시킬 수 있다.
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